Clozapine Combined with Paliperidone Observations in Schizophrenic Patients with Insufficient Responses to Clozapine Monotherapy
نویسندگان
چکیده
Treatment resistance to clozapine often leads to antipsychotic combinations. Well-designed trials evaluated the add-on of several atypical antipsychotics, but the augmentation with paliperidone, the active metabolite of risperidone, has never been evaluated. Treatment of four cases resulted in a decrease of the PANSS-positive subscale, the mean initial clozapine dose could be lowered, mean prolactin increased, but the observed general tolerance was good. In conclusion, combined antipsychotic treatment with CLZ and PAL might be a successful strategy in individual patients, but efficacy and tolerance should be further evaluated in controlled clinical trials (German J Psychiatry 2010; 13: 37-).
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